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| Souza-Braga,P.; Lorena,F.B.; Nascimento,B.P.P.; Marcelino,C.P.; Ravache,T.T.; Ricci,E.; Bernardi,M.M.; Ribeiro,M.O.. |
| Attention and emotion have a positive impact on memory formation, which is related to the activation of the noradrenergic system in the brain. The hippocampus and amygdala are fundamental structures in memory acquisition, which is modulated by noradrenaline through the noradrenergic receptors. Pharmacological studies suggest that memory acquisition depends on the action of both the β3 (β3-AR) and β2 (β2-AR) receptor subtypes. However, the use of animal models with specific knockout for the β3-AR receptor only (β3-ARKO) allows researchers to more accurately assess its role in memory formation processes. In the present study, we evaluated short- and long-term memory acquisition capacity in β3-ARKO mice and wild-type mice at approximately 60 days of age. The... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Adrenergic receptors; Memory; GLUT3; Β3-AR. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001000607 |
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| Bocco,B.M.; Fernandes,G.W.; Lorena,F.B.; Cysneiros,R.M.; Christoffolete,M.A.; Grecco,S.S.; Lancellotti,C.L.; Romoff,P.; Lago,J.H.G.; Bianco,A.C.; Ribeiro,M.O.. |
| Fractionation of the EtOH extract from aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to isolation of caffeic and ferulic acids, which were identified from spectroscopic and spectrometric evidence. These compounds exhibit antioxidant and anti-inflammatory properties and have been shown to be effective in the prevention/treatment of metabolic syndrome. This study investigated whether the combined treatment of caffeic and ferulic acids exhibits a more significant beneficial effect in a mouse model with metabolic syndrome. The combination treatment with caffeic and ferulic acids was tested for 60 days in C57 mice kept on a high-fat (40%) diet. The data obtained indicated that treatment with caffeic and ferulic acids prevented gain in body weight... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Obesity; Caffeic acid; Ferulic acid; Metabolic syndrome. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000300604 |
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